Azole antifungal agents are known to cause QT-interval prolongation and in some cases subsequent torsade de pointes through inhibition of cardiac hERG (human ether receptor a go-go) potassium channels2.
Table of Contents
Which antifungals cause QT prolongation?
Azole antifungal agents are known to cause QT-interval prolongation and in some cases subsequent torsade de pointes through inhibition of cardiac hERG (human ether receptor a go-go) potassium channels2.
Does fluconazole increase QT?
Fluconazole causes QT prolongation via the inhibition of Rectifier Potassium Channel current (Ikr). The QT prolongation caused by other medicinal products (such as amiodarone) may be amplified via the inhibition of cytochrome P450 (CYP) 3A4.
Does fluconazole prolonged QT interval?
Fluconazole is an anti-fungal drug reported to cause QT interval prolongation and torsades de pointes in adults.
Which fluoroquinolone has the most QTc prolongation?
According to the available case reports and clinical studies, moxifloxacin carries the greatest risk of QT prolongation from all available quinolones in clinical practice and it should be used with caution in patients with predisposing factors for Torsades de pointes (TdP).
Which azole shortens QTc?
Mycoses.
Do tetracyclines prolong QT?
Of the macrolides, azithromycin,17, 18 clarithromycin,19, 20 erythromycin21, 22 and roxithromycin23 have all been shown to prolong the QT interval. Doxycycline, a tetracycline antibiotic, should be considered to replace azithromycin or roxithromycin for treatment of atypical pneumonia.
How long does Cipro prolong QT?
Conclusion
| Ref . | Age/Sex . | Time Elapsed to Detection of Q-T Prolongation . |
|---|---|---|
| 44/female | Within several hr of initiation | |
| 17 | 22/male | Within 2 days of initiation |
| 18 | 76/male | Within 1 day of course completion |
| 19 | 70/female | Within 3 days of initiation |
How much does ciprofloxacin prolong QT?
Ciprofloxacin does not Prolong the QTc Interval: A Clinical Study in ICU Patients and Review of the Literature. J Pharm Pharm Sci. 2017;20(1):360-364.
Does Cipro prolong QTc?
Ciprofloxacin and fluconazole combination therapy is frequently used as prophylaxis for, and treatment of, infections in patients with haematological malignancies. However, both drugs are known to prolong the heart rate-corrected QT (QTc) interval, which is a serious risk factor for torsade de pointes (TdP).
Does levofloxacin increase QTc?
Conclusions: Neither levofloxacin nor ciprofloxacin significantly prolonged the mean QTc interval over baseline. When electrolyte deficiencies in one of the patients evaluated were taken into account, this also held true for the longest QTc interval.
Does micafungin prolong QT?
What is new and conclusion: This is the first known case of polymorphic ventricular tachycardia with micafungin as the possible cause. Clinicians should be aware of this potential adverse event and monitor patients receiving concomitant drugs that can prolong QT interval.
Does isavuconazole prolong QTc?
Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner.
Does Flagyl prolong QTc?
Metronidazole is a widely used antimicrobial medication and is a potent inhibitor of CYP3A4 and CYP2C9 isoenzymes. Theoretically, it may cause QT prolongation by inhibiting the metabolism of other drugs that have potential to cause QT prolongation.
Does voriconazole prolong QTc?
Conclusions: Concomitant therapy with amiodarone and voriconazole significantly prolonged the QTc interval to a degree greater than that on monotherapy.
Do tetracyclines cause QT prolongation?
Which drugs cause QTc prolongation?
Table 2 Some drugs associated with QTc prolongation
- Antibiotics. azithromycin. clarithromycin. erythromycin. roxithromycin. metronidazole. (with alcohol) moxifloxan.
- Antifungals. fluconazole. (in cirrhosis) ketoconazole.
- Antivirals. nelfinavir.
- Antimalarials. chloroquine. mefloquine.
Does amphotericin B prolong QT?
Amphotericin B® treatment causes QT prolongation in lung transplant-patients – PMC. The .
Does Cresemba prolong QTc?
Abstract. Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner.
Which antibiotics prolong QTc?
Ketoconazole, itraconazole, fluconazole, and voriconazole have been shown to prolong the QT interval and to be associated with TdP, with the majority of reports of TdP stemming from drug interactions and involving ketoconazole and itraconazole [74–88]. Akin to the macrolides, the azoles are “dual-risk” agents.