Dual pH and thermo-responsive carriers are being considered as next-generation drug delivery systems, which are capable of releasing drugs intelligently in response to external or internal stimuli. These systems are characterized by minimal toxicity, improved therapeutic efficacy and reduced exposure to normal cells.

What is pH responsive and temperature responsive delivery?

Dual pH and thermo-responsive carriers are being considered as next-generation drug delivery systems, which are capable of releasing drugs intelligently in response to external or internal stimuli. These systems are characterized by minimal toxicity, improved therapeutic efficacy and reduced exposure to normal cells.

What is matrix system in drug delivery?

In general, the term matrix device implies a drug delivery system in which the drug is dispersed, either molecularly or as solid drug particles, within a polymer network. Within this context at least four different types of devices can be envisioned.

What is pH responsive drug delivery system?

pH-Responsive drug-delivery systems have attracted more and more interest as “smart” drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy.

How do pH sensitive polymers work?

pH sensitive or pH responsive polymers are materials which will respond to the changes in the pH of the surrounding medium by varying their dimensions. Materials may swell, collapse, or change depending on the pH of their environment.

What are redox responsive polymers?

Redox-Responsive Polymers. Redox-responsive stimuli are most important for disease therapy and are widely used in polymer drug delivery systems. The disulfide linker is reduction-sensitive and readily cleaved by a high concentration of GSH.

What is matrix and reservoir?

In a matrix or monolithic delivery system the drug is either molecular dissolved or dispersed inside a matrix. Compared to a reservoir system, a matrix system is not enveloped within a rate limiting membrane. As such the release rate of the drug from the matrix system is normally not constant and decreases in time.

What is meant by pH sensitive?

What is Gastroretentive drug delivery system?

Gastro retentive delivery systems are designed to be retained in the stomach for a prolonged time and release their active ingredients and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal (GI) tract.

What do temperature responsive polymers do?

Temperature-responsive polymers or thermoresponsive polymers are polymers that exhibit a drastic and discontinuous change of their physical properties with temperature. The term is commonly used when the property concerned is solubility in a given solvent, but it may also be used when other properties are affected.

What is redox responsive?

Redox responsive drug delivery systems (DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower.

Can oxygen be oxidized or reduced?

Oxygen is therefore an oxidizing agent. Oxidizing and reducing agents therefore can be defined as follows. Oxidizing agents gain electrons. Reducing agents lose electrons.

What is reservoir system?

In this discussion, a reservoir system is a water–hydrocarbon system contained within the pores of a rock unit. A reservoir system has three main components: a reservoir, an aquifer, and a transition zone (interface) between the two.

What is reservoir drug delivery system?

Reservoir-based systems include a subset of microfabricated drug delivery systems and provide unique advantages. Reservoirs, whether external to the body or implanted, provide a well-controlled environment for a drug formulation, allowing increased drug stability and prolonged delivery times.