What does Napsin a positive mean?

What does Napsin a positive mean?

Background. Napsin A and thyroid transcription factor-1 (TTF-1) are known to be useful immunohistochemical markers to distinguish primary lung cancers from metastatic lung tumors. These markers are usually positive in primary lung adenocarcinomas but not metastatic adenocarcinomas in other organs.

What is Napsin A?

Napsin A is a newly discovered functional aspartic proteinase that is expressed in normal lung parenchyma in type II pneumocytes and is thought to be associated with primary lung adenocarcinoma. Thyroid transcription factor-1 (TTF-1) is a widely used relatively restricted marker for lung adenocarcinoma.

What is p63 immunohistochemistry?

Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.

What CK20 negative?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What does CK20 positive mean?

What is p63 a marker of?

Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the identification of myoepithelial cells in other tissues including the breast. p63 is also a marker for squamous cell carcinoma.

What is p63 positive mean?

P63: scored positive when high intensity staining was present on ≥50% of tumor cells; the remainder was scored negative [10]. TTF-1: scored positive when staining was present on ≥5% of tumor cells; the remainder was scored negative [11].

What are the 4 types of cancers?

Four main types of cancer are:

  • Carcinomas. A carcinoma begins in the skin or the tissue that covers the surface of internal organs and glands.
  • Sarcomas. A sarcoma begins in the tissues that support and connect the body.
  • Leukemias. Leukemia is a cancer of the blood.
  • Lymphomas.

What CK20 positive?

CK20 (negative/rare positive): Most breast, lung, and salivary gland carcinomas, hepatocellular, renal, prostate, adrenocortical, squamous, and small cell carcinomas. SeeBox 8.1 for CK7/CK20 immunoprofile of various carcinomas.

What is CK7 and CK20?

CK7 is present in various ductal and glandular epithelia, including the lung, breast, skin appendages, salivary gland, pancreas, ovary, and endometrium. CK20 is widely expressed in mucosal cells of the gastrointestinal and urinary tract.

What is CK and CK7?

Cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) are low molecular weight cytokeratins. Their anatomic distribution is generally restricted to epithelia and their neoplasms. We surveyed 435 epithelial neoplasms from various organ systems by immunohistochemistry using CK 7 and CK 20 monoclonal antibodies.

What is TTF positive?

Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.

What is immunohistochemistry with TTF-1?

Thyroid transcription factor-1 (TTF-1) is expressed in lung adenocarcinomas and thyroid carcinomas but not in adenocarcinomas arising from other sites. For patients with adenocarcinomas in the lung, TTF-1 staining is now routinely used to distinguish a primary lung cancer from a lung metastasis.

What is CDX2 and CK20?

CDX2 is a sensitive marker for rectal origin of adenocarcinoma. It can be helpful in cases with metastatic rectal carcinoma, especially those with CK7+/CK20+ or CK20-/CK7- immunophenotype. In this study, CDX2 expression was not influenced by the grade (differentiation) of rectal adenocarcinoma.