## How do you convert Lantus to NPH?

Long-acting to NPH Convert unit-per-unit,3 or reduce dose by 20%. Give NPH twice daily (e.g., 50:50 or 2/3 in AM and 1/3 before dinner or at bedtime). Convert unit-per-unit from Lantus,3 or reduce dose by 20%.

## How do I transition to U-500?

Subtract 10% to 20% from this sum to use for initial dosing. Next, divide by 500 to arrive at the number of mL to administer per day. Finally, divide this daily total in 2 to 3 doses. For example, a patient injecting a total of 250 U of U-100 converts to 0.2 mL of U-500 injected twice daily.

How many units of insulin are in U-500?

Humulin R U-500 contains 500 units of insulin in each milliliter (5 times more concentrated than Humulin® R U-100). For Humulin R U-500, extreme caution must be observed in the measurement of dosage because inadvertent overdose may result in serious adverse reaction or life-threatening hypoglycemia.

### How many units are in a Lantus?

Each ml contains 100 units insulin glargine* (equivalent to 3.64 mg). Each vial contains 5 ml of solution for injection, equivalent to 500 units, or 10 ml of solution for injection, equivalent to 1000 units.

### Are NPH and Lantus the same?

Glargine (Lantus) is an insulin analog recently available in the U.S. It is a long-acting insulin but differs from other long-acting insulins (such as NPH, Lente, and ultralente) because it is clear as opposed to cloudy.

How do you calculate Lantus?

Our dose calculation formula is expressed as: [optimal daily dose of insulin glargine at 24 weeks] = starting dose (0.15×weight) + incremental dose (baseline HbA1c – target HbA1c+2).

## How do you switch between insulins?

When switching from an intermediate-acting to a once a day long-acting insulin, add up the total amount of intermediate-acting insulin units for one day, and give it as a single long-acting insulin dose once a day.

## What type of insulin is U-500?

U-500 regular insulin (U-500R) is five-fold concentrated, such that each 1 ml contains 500 units of insulin. Therefore, the volume of insulin injected is reduced by 80%, resulting in fewer injections and less discomfort, as well as potentially improved insulin absorption.

How does U-500 differ from U-100 insulin?

U-500 is 5 times more concentrated than standard U-100 insulin. When insulin is concentrated, it takes less liquid per dose than standard U-100 insulin to help reduce your blood sugar levels. With U-500, you can inject up to 80% less liquid and still get the dose you need.

### How many ml are in a U-500 vial?

U-500 insulin comes in 20-ml vials (twice as big as U-100 insulin vials) and has orange stripes on the box and label. Make sure you are also using the correct syringes.

### How many units are in 100 ml of Lantus?

Each ml contains 100 units insulin glargine* (equivalent to 3.64 mg).

Is Humulin N the same as Lantus?

Humulin R is a short-acting form of insulin and Lantus is a long-acting form of insulin.

## How do you convert insulin?

1. Substituting with an intermediate-acting insulin: Give 70% of total units for each dose.
2. Substituting with a long-acting insulin: Add up the total insulin units given in one day. Give 70% as one daily dose.

## What happens if you switch insulins?

Changing your insulin can alter your blood sugar control for a few days or months. You will likely need to test your blood sugar more often until your body gets used to the new insulin.

Is Semglee equivalent to Lantus?

Semglee (insulin glargine-yfgn) is both biosimilar to, and interchangeable with (can be substituted for), its reference product Lantus (insulin glargine), a long-acting insulin analog. Semglee (insulin glargine-yfgn) is the first interchangeable biosimilar product approved in the U.S. for the treatment of diabetes.

### Which insulin is available as 500 units ml?

Human regular U-500 insulin (U-500), a fivefold concentrated form of U-100 regular human insulin, was introduced to address the insulin needs of patients with severe insulin resistance (1).

### Is optisulin a Lantus?

Optisulin is the same formulation and delivery device as Lantus (cartridges for reusable injector pen devices).

What insulin is comparable to Lantus?